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Referral and warning signs
When to refer
Urgent Referral: Any child classified as Very Severe Febrile Disease OR Severe Complicated Measles. Child with Malaria or Fever-No Malaria who develops danger signs or fails to improve on follow-up. Fever present every day for >7 days. Child with complicated measles (eye/mouth) not improving on follow-up.
Red flags
- Any General Danger Sign.
- Stiff neck.
- Severe complicated measles signs (clouding of cornea, deep mouth ulcers).
- High fever unresponsive to paracetamol.
- Signs of shock or severe dehydration.
Signs and symptoms
- Ask:
- - Does the child have fever (by history, feels hot, or measured temp >=37.5°C)?
- - If yes, for how long?
- - If >7 days, has fever been present every day?
- - Has the child had measles within the last 3 months?
- Look and Feel:
- - Look or feel for stiff neck.
- - Look for runny nose.
- - Look for any bacterial cause of fever (local tenderness, oral sores, refusal to use limb, hot tender swelling, red tender skin/boils, abdominal/urinary pain).
- - Look for signs of MEASLES (Generalized rash AND Cough, Runny nose, or Red eyes).
- - If Measles now or within 3 months:
- - Look for mouth ulcers (deep or extensive?).
- - Look for pus draining from eyes.
- - Look for clouding of the cornea.
Risk factors
- Living in or travel to malaria-endemic area.
- Lack of immunization (Measles, Pneumococcal, Hib).
- Malnutrition.
- HIV infection.
Diagnosis
Clinical assessment
Assessment based on presence/absence of general danger signs, stiff neck, malaria test result, duration of fever, presence of localizing signs of bacterial infection, and signs of measles or its complications.
Investigations
- Malaria Test (RDT or Microscopy): MANDATORY for all fever cases.
- Temperature measurement.
- Lumbar Puncture (Referral level, if meningitis suspected based on danger signs/stiff neck).
- Other investigations based on suspected local cause (e.g., urinalysis, CXR - referral level).
Diagnostic criteria
IMCI Classification based on signs: - Very Severe Febrile Disease: Any General Danger Sign OR Stiff neck. - Malaria: Positive Malaria Test. - Fever - No Malaria: Negative Malaria Test. - Severe Complicated Measles: Measles now or <3m ago AND (Any General Danger Sign OR Clouding of cornea OR Deep/extensive mouth ulcers). - Measles + Eye or Mouth Complications: Measles now or <3m ago AND (Pus draining from eye OR Mouth ulcers). - Measles: Measles now or <3m ago AND none of the above complications.
Management
Non-pharmacological management
- All Fever: Advise mother on home care (fluids, feeding), when to return immediately (danger signs). Counsel on mosquito net use and environmental sanitation.
- Measles: Encourage fluid intake, continue feeding.
- Very Severe Febrile Disease: Keep warm, prevent low blood sugar during referral.
Pharmacological treatment
- Very Severe Febrile Disease:
- - Give FIRST DOSE pre-referral antimalarial: Rectal Artesunate (10 mg/kg) OR IM/IV Artesunate (3 mg/kg if <20kg, 2.4 mg/kg if >20kg).
- - Give FIRST DOSE pre-referral antibiotic: Ampicillin 50 mg/kg IM + Gentamicin 7.5 mg/kg IM (HC3+) OR Benzylpenicillin 50,000 IU/kg IM (HC2).
- - Give Paracetamol 10-15 mg/kg for high fever (>=38.5°C).
- - Treat convulsions if present (Rectal Diazepam).
- - Refer URGENTLY to Hospital.
- Malaria:
- - Give first-line oral ACT (Artemether-Lumefantrine - AL) - Dose by weight/age band (See UCG 2.5.2).
- - Give Paracetamol 10-15 mg/kg for high fever (>=38.5°C).
- - Treat any identified co-existing bacterial infection.
- - Follow up in 3 days if fever persists (reassess, check adherence, consider referral/2nd line if needed). Refer if fever >7 days.
- Fever - No Malaria:
- - Give Paracetamol 10-15 mg/kg for high fever (>=38.5°C).
- - Treat identified bacterial infection if present.
- - If no bacterial cause, reassure, advise paracetamol for fever, follow up in 3 days if fever persists (reassess, repeat malaria test, consider referral). Refer if fever >7 days.
- Severe Complicated Measles:
- - Give Vitamin A (Age-appropriate dose - See Nutrition/Vit A section).
- - Give FIRST DOSE pre-referral antibiotic (as for Very Severe Febrile Disease).
- - If eye signs (clouding/pus): Apply Tetracycline eye ointment 1%.
- - Refer URGENTLY to Hospital.
- Measles + Eye or Mouth Complications:
- - Give Vitamin A.
- - If pus from eye: Apply Tetracycline eye ointment 1% TID.
- - If mouth ulcers: Apply Gentian Violet 0.5% paint BID.
- - Follow up in 3 days (assess eye/mouth, check treatment, refer if worse/not improving).
- Measles (Uncomplicated):
- - Give Vitamin A.
- - Advise mother on home care.
Monitoring
Follow-up as per classification (usually 3 days if fever persists). Reassess danger signs, temperature, feeding, other symptoms. Monitor response to antimalarials/antibiotics.
Complications
- Severe malaria.
- Meningitis.
- Sepsis.
- Pneumonia.
- Dehydration.
- Febrile convulsions.
- Complications of measles (pneumonia, diarrhoea, encephalitis, blindness, malnutrition).
Prevention
- Malaria prevention (LLINs, prompt treatment).
- Immunization (Measles, PCV, Hib).
- Good nutrition.
- Hygiene and sanitation.
Patient education
- Diagnosis (Malaria vs other fever vs Measles).
- How to give prescribed medicines (ACT, Paracetamol, antibiotics, Vitamin A, eye ointment, GV paint).
- Importance of completing full course of treatment.
- How to manage fever at home (tepid sponging, paracetamol).
- Need for increased fluids and continued feeding.
- Danger signs requiring immediate return.
- Importance of follow-up visit.
- Malaria prevention (nets) and measles prevention (vaccination).
Uganda-specific notes
Malaria is the most common cause of fever; universal testing (RDT/microscopy) before treatment is policy. Prompt treatment of malaria with ACTs is crucial. Recognizing severe disease needing referral is key. Measles outbreaks still occur. Vitamin A supplementation with measles is vital.
References
- Uganda Clinical Guidelines (UCG) 2023
Chapter 17, Section 17.3.4
- Uganda Clinical Guidelines (UCG) 2023
Chapter 2, Section 2.5.2 (Malaria Treatment)
- Uganda Clinical Guidelines (UCG) 2023
Chapter 2, Section 2.3.3 (Measles & Vitamin A)
- IMCI Chart Booklet, MOH Uganda
(Fever Algorithm)