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Referral and warning signs
When to refer
Urgent Referral: Any child classified with Severe Dehydration OR Severe Persistent Diarrhoea OR Dysentery not improving after 3 days OR Any child with diarrhoea AND a General Danger Sign. Refer child with Persistent Diarrhoea (no dehydration) if not improving after 5 days. Refer child with Some Dehydration if associated with another severe classification or cannot drink.
Red flags
- Any General Danger Sign.
- Signs of Severe Dehydration.
- Blood in stool.
- Diarrhoea >= 14 days.
- Signs of shock (cold extremities, weak pulse, delayed capillary refill).
Signs and symptoms
- Ask:
- - Does the child have diarrhoea?
- - If yes, for how long?
- - Is there blood in the stool?
- Look and Feel (Assess for Dehydration):
- - General Condition: Lethargic or unconscious? Restless or irritable?
- - Eyes: Sunken?
- - Thirst: Offers fluids - Unable to drink or drinks poorly? Drinks eagerly, thirsty?
- - Skin Pinch (Abdomen): Goes back very slowly (>2 sec)? Goes back slowly (<2 sec)?
Risk factors
- Poor sanitation and hygiene.
- Contaminated water or food.
- Malnutrition.
- Lack of immunization (Rotavirus).
- HIV infection.
- Lack of exclusive breastfeeding (<6 months).
Diagnosis
Clinical assessment
History of diarrhoea duration and presence of blood. Assessment of dehydration level based on general condition, eyes, thirst, and skin pinch.
Investigations
- Clinical assessment using IMCI algorithm is primary.
- Stool microscopy/culture (usually referral level, indicated for persistent diarrhoea or dysentery not responding to treatment).
- Electrolytes (referral level, if severe dehydration or IV fluids needed).
Diagnostic criteria
IMCI Classification based on signs: Dehydration: - Severe Dehydration: Any 2 signs: Lethargic/unconscious, Sunken eyes, Unable to drink/drinks poorly, Skin pinch >2 sec. - Some Dehydration: Any 2 signs: Restless/irritable, Sunken eyes, Drinks eagerly/thirsty, Skin pinch <2 sec. - No Dehydration: Not enough signs for Some or Severe. Duration/Blood: - Severe Persistent Diarrhoea: Diarrhoea >=14 days AND Dehydration present. - Persistent Diarrhoea: Diarrhoea >=14 days AND No Dehydration. - Dysentery: Blood in stool.
Management
Non-pharmacological management
- All Diarrhoea:
- - Fluid Management: Based on dehydration level (Plan A, B, or C).
- - Zinc Supplementation: Give Zinc 20mg (1 tab) daily for 10 days (Age >6m) OR 10mg (1/2 tab) daily for 10 days (Age 2-6m).
- - Continued Feeding: Continue breastfeeding frequently. Continue usual feeds, offer food more frequently.
- - Counsel mother on danger signs and when to return immediately.
- - Counsel on hygiene and sanitation.
- Plan A (No Dehydration): Home management. Give extra fluids (ORS after each stool, age-appropriate amounts), continue feeding, Zinc. Follow up 5 days if not improving.
- Plan B (Some Dehydration): Facility-based ORS therapy over 4 hours (approx. 75ml/kg). Reassess frequently. Start feeding after 4 hours. Teach Plan A for home. Follow up 5 days if not improving.
- Plan C (Severe Dehydration): Urgent IV fluid resuscitation (Ringer's Lactate or Normal Saline 100ml/kg divided - see Emergencies chapter 1.1.3). Start ORS when able to drink. Reassess frequently. If IV not possible, NGT ORS (20ml/kg/hr for 6h) or urgent referral. If cholera suspected, give antibiotic.
- Persistent Diarrhoea: Advise on specific feeding recommendations (nutrient-dense foods). Give multivitamins + Zinc for 14 days. Give Vitamin A. Follow up 5 days. If dehydrated or not improving, refer.
- Dysentery: Treat dehydration if present. Give Ciprofloxacin (see below). Follow up 3 days.
Pharmacological treatment
- Oral Rehydration Salts (ORS): Essential for all dehydration plans. Prepare and give as instructed.
- Zinc Sulphate: 10mg (2-6m) or 20mg (>6m) daily for 10 days for ALL diarrhoea cases.
- Dysentery: Ciprofloxacin 15 mg/kg PO BID for 3 days.
- Cholera (Suspected, Severe Dehydration, Age >=2y): Add Erythromycin 12.5 mg/kg QID for 3 days (or alternative based on local sensitivity - Doxycycline/Azithromycin often used in adults).
- Severe Persistent Diarrhoea: Vitamin A dose + Multivitamins including Zinc for 14 days.
- Severe Dehydration (IV Fluids): Ringer's Lactate or Normal Saline (0.9% NaCl) - refer to specific IV fluid protocols (UCG 1.1.3.1).
Monitoring
Monitor hydration status frequently during rehydration (Plan B/C). Follow up as per classification (3 days dysentery, 5 days others if not improving). Assess feeding and weight. Monitor response to antibiotics if given.
Complications
- Severe dehydration -> Shock, Renal failure, Death.
- Electrolyte imbalance (hypokalaemia, hypernatraemia).
- Malnutrition.
- Persistent diarrhoea.
- Haemolytic Uraemic Syndrome (HUS - rare, with E.coli O157).
Prevention
- Exclusive breastfeeding for 6 months.
- Improved sanitation and access to clean water.
- Handwashing with soap.
- Safe food preparation.
- Rotavirus vaccination.
- Measles vaccination.
- Vitamin A supplementation.
Patient education
- How to prepare and give ORS (frequent small sips).
- Importance of Zinc for 10 days.
- Need for continued feeding (more frequent small meals).
- Signs of dehydration and when to return immediately.
- Hygiene measures (handwashing, safe water/food).
- How to give antibiotics if prescribed (Ciprofloxacin for dysentery).
Uganda-specific notes
Diarrhoea is a major killer of children under 5. Promotion of ORS + Zinc is critical. Rotavirus vaccine is included in EPI. Shigella is a common cause of dysentery; Ciprofloxacin is first-line. Cholera outbreaks occur periodically.
References
- Uganda Clinical Guidelines (UCG) 2023
Chapter 17, Section 17.3.3
- Uganda Clinical Guidelines (UCG) 2023
Chapter 1, Section 1.1.3.1 (Dehydration Plans)
- IMCI Chart Booklet, MOH Uganda
(Diarrhoea Algorithm)