Fever - No Malaria 2 months - 5 years
Routine Management / Treat underlying cause if identified
High match
What to tell caregiver
- If bacterial cause identified: Explain diagnosis and need for antibiotic. Teach how to give antibiotic correctly.
- If no bacterial cause identified: Explain likely viral cause, reassure that antibiotics are not needed. Explain that fever may last a few days.
- Teach how to give Paracetamol for high fever at home (correct dose, frequency max every 6 hours).
- Advise on increasing fluids and continuing feeding.
- Advise WHEN TO RETURN IMMEDIATELY: Develops danger signs, develops stiff neck, becomes sicker, fever persists > 3 days without improving at all, or develops localizing signs.
- Advise to return in 3 days if fever persists.
Classification for a child presenting with fever (or history/hot/temp ≥37.5°C) who has a negative malaria test OR malaria test was not done but no obvious cause of fever identified, AND no signs of Very Severe Febrile Disease. Requires management of fever and identification/treatment of any other bacterial cause.
Key Features
- Fever (current or recent history).
- Malaria test is negative (or not done but malaria unlikely/ruled out clinically where appropriate).
- Absence of any general danger sign or stiff neck.
- Need to search for and treat other potential causes of fever.
- If no cause found, likely viral, manage symptomatically.
Red Flags (Warning Signs)
- Development of any danger sign or stiff neck.
- Fever persisting > 3 days without improvement.
- Fever present every day for more than 7 days.
- Fever present for 14 days or more (check for TB).
Assessment
Ask
-
Does the child have fever (by history, feels hot, or temperature ≥37.5°C)?
-
Confirm absence of General Danger Signs.
-
Confirm absence of Stiff Neck.
-
Perform Malaria Test (RDT or Microscopy) - Result is NEGATIVE OR test not done.
-
Look for other causes of fever (e.g., signs of pneumonia, ear infection, UTI symptoms, skin infection, throat infection).
Classification
- Fever present AND Malaria test NEGATIVE (or not done/available) AND Other cause of fever PRESENT -> FEVER - NO MALARIA (Treat the identified cause)
- Fever present AND Malaria test NEGATIVE (or not done/available) AND No other cause of fever identified -> FEVER - NO MALARIA (Likely Viral)
Urgency / Refer urgently
Routine Management / Treat underlying cause if identified
Management
Non-Pharmacological Management
- Advise adequate fluid intake.
- Continue feeding.
- Advise tepid sponging for comfort if high fever (optional).
Pharmacological Treatment
- Give one dose of Paracetamol (10-15 mg/kg) in the clinic if high fever (≥38.5°C axillary) - see dosage on page 15.
- If an identified bacterial cause of fever is present (e.g., Pneumonia, Acute Ear Infection, Dysentery): Give appropriate antibiotic treatment for that condition (refer to relevant sections/pages for drug, dose, duration - e.g., Amoxicillin for Pneumonia/AOM, Ciprofloxacin for Dysentery).
- If fever is present every day for > 7 days, refer for further assessment.
- If fever is present for > 14 days, check for TB (assess symptoms, contact history - see page 9).
Monitoring & Follow-Up
- Follow-up in 3 days IF fever persists.
- At follow-up: Reassess child fully (check danger signs, stiff neck, source of fever). If danger signs/stiff neck, treat as Very Severe Febrile Disease and refer. If fever persists without source, reassess carefully, consider referral if >7 days total or child unwell. If another cause identified, treat. If improving, reassure.
- Advise mother when to return immediately.
Counselling Points
- If bacterial cause identified: Explain diagnosis and need for antibiotic. Teach how to give antibiotic correctly.
- If no bacterial cause identified: Explain likely viral cause, reassure that antibiotics are not needed. Explain that fever may last a few days.
- Teach how to give Paracetamol for high fever at home (correct dose, frequency max every 6 hours).
- Advise on increasing fluids and continuing feeding.
- Advise WHEN TO RETURN IMMEDIATELY: Develops danger signs, develops stiff neck, becomes sicker, fever persists > 3 days without improving at all, or develops localizing signs.
- Advise to return in 3 days if fever persists.
Differential Diagnosis
- Viral URTI / LRTI (Flu, adenovirus etc.)
- Pneumonia
- Acute Otitis Media
- Urinary Tract Infection (UTI)
- Tonsillitis/Pharyngitis (Bacterial or Viral)
- Skin and soft tissue infection (abscess, cellulitis)
- Gastroenteritis (may have fever)
- Typhoid fever
- Tuberculosis (if prolonged fever)
- Other less common infections (e.g., Brucellosis, Rickettsial)
- Non-infectious causes (rare in this context - e.g., Kawasaki disease)
Potential Complications
- Febrile convulsions
- Dehydration
- Complications related to the underlying cause of fever (e.g., mastoiditis from ear infection, pyelonephritis from UTI).
Prevention
- Immunizations.
- Handwashing, hygiene.
- Good nutrition.
- Malaria prevention (reduces malaria as cause, helps focus on other causes).
- Prompt care seeking.
Reference: IMCI Chart Booklet - Page 4, Page 9 (TB), Page 15 (Paracetamol), Page 23 (Follow-up), Page 30 (Return signs)
Very Severe Febrile Disease 2 months - 5 years
Refer URGENTLY
High match
What to tell caregiver
- Explain the extreme seriousness of the child's condition and the urgent need for hospital care.
- Explain treatments given (antimalarial, antibiotic, sugar, paracetamol if given).
- Advise on keeping the child warm during transport.
- Advise on continuing breastfeeding if possible.
- Write a detailed referral note listing findings, classifications, and all treatments given (drug, dose, time).
Classification for a child presenting with fever (or history of fever/feels hot/temp ≥37.5°C) who has any general danger sign OR a stiff neck. This indicates a potentially life-threatening infection (like severe malaria, meningitis, sepsis) requiring immediate pre-referral treatment and urgent referral.
Key Features
- Presence of Fever (current or recent history).
- Presence of ANY General Danger Sign OR a Stiff Neck.
- Stiff neck strongly suggests meningitis.
- Requires immediate pre-referral antimalarial, antibiotic, and hypoglycemia prevention, followed by urgent referral.
Red Flags (Warning Signs)
- Any general danger sign
- Stiff neck
- Impaired consciousness / lethargy
- Convulsions
- Signs of shock
Assessment
Ask
-
Does the child have fever (by history, feels hot, or temperature ≥37.5°C)?
Look, listen, feel
-
Look or feel for stiff neck (difficulty or pain when gently flexing the neck forward).
-
Check for General Danger Signs (Any ONE: Unable to drink/breastfeed, Vomits everything, Had convulsions, Lethargic/unconscious, Convulsing now).
Classification
- Fever present AND (Any general danger sign OR Stiff neck) -> VERY SEVERE FEBRILE DISEASE
Urgency / Refer urgently
Refer URGENTLY
Pre-referral treatment
- Give 1st dose of pre-referral antimalarial: Rectal Artesunate (10 mg/kg) OR IM/IV Artesunate (3 mg/kg if =20kg) OR IM Quinine (see page 11 for specific dosing based on formulation).
- Give 1st dose of appropriate IM antibiotic: Ampicillin (50 mg/kg) AND Gentamicin (7.5mg/kg) OR alternative based on local guidelines (e.g., Ceftriaxone). See page 12 for Ampicillin/Gentamicin dosing.
- Treat child to prevent low blood sugar: If child can breastfeed, ask mother. If cannot breastfeed but can swallow, give 30-50ml EBM/substitute/sugar water (4 tsp sugar in 200ml water). If cannot swallow, give 50ml via NG tube.
- Give one dose of Paracetamol (10-15 mg/kg) if high fever (≥38.5°C axillary). Dosage (500mg tablet): 2-3m (<6kg): 1/4 tab. 4m-3y (6-<14kg): 1/2 tab. 4-5y (14-19kg): 3/4 tab (or 1/2 of 500mg tab from p15). Note: page 15 suggests 10mg/kg for paracetamol, use local guideline preference.
- If convulsing now, give rectal Diazepam (see page 11 for dose).
Management
Non-Pharmacological Management
- Quickly complete assessment.
- Ensure airway is clear, position appropriately.
- Keep child warm.
Monitoring & Follow-Up
- To be managed at referral hospital facility.
Counselling Points
- Explain the extreme seriousness of the child's condition and the urgent need for hospital care.
- Explain treatments given (antimalarial, antibiotic, sugar, paracetamol if given).
- Advise on keeping the child warm during transport.
- Advise on continuing breastfeeding if possible.
- Write a detailed referral note listing findings, classifications, and all treatments given (drug, dose, time).
Differential Diagnosis
- Severe Malaria (Cerebral malaria)
- Bacterial Meningitis
- Sepsis
- Severe Pneumonia (may present with fever and danger signs)
- Typhoid fever (severe)
- Encephalitis
- Other severe systemic infections
Potential Complications
- Coma
- Permanent neurological damage (from meningitis, cerebral malaria, hypoglycemia)
- Shock
- Severe anaemia (malaria)
- Kidney failure
- Respiratory failure
- Death
Prevention
- Use of Insecticide Treated Nets (ITNs).
- Prompt diagnosis and treatment of uncomplicated malaria.
- Immunizations (Hib, Pneumococcal, Meningococcal if available/indicated).
- Good nutrition.
- Prompt care seeking for any fever.
Reference: IMCI Chart Booklet - Page 4, Pages 1, 11, 12, 15
Malaria 2 months - 5 years
Routine Management / Treat with ACT
High match
What to tell caregiver
- Explain the diagnosis (malaria) and the need for antimalarial tablets.
- Teach how to give the full course of ACT correctly: dose, timing (especially for AL's 8-hour second dose), duration (3 days), importance of giving with food for AL.
- Teach how to give Paracetamol for high fever.
- Advise on increasing fluids and continuing feeding.
- Advise WHEN TO RETURN IMMEDIATELY: Develops danger signs (cannot drink, vomits everything, convulsions, lethargy), develops stiff neck, becomes sicker.
- Advise to return in 3 days if fever persists, or sooner if condition worsens.
Classification for a child presenting with fever (or history/hot/temp ≥37.5°C) who has a positive malaria test (RDT or microscopy) and NO signs of Very Severe Febrile Disease. Requires treatment with a recommended first-line antimalarial.
Key Features
- Fever (current or recent history).
- Positive malaria diagnostic test.
- Absence of any general danger sign or stiff neck.
- Requires treatment with oral Artemisinin-based Combination Therapy (ACT).
Red Flags (Warning Signs)
- Development of any danger sign or stiff neck (indicates progression to severe malaria/disease).
- Persistent vomiting preventing oral medication.
- Fever persisting after 3 days of treatment.
Assessment
Ask
-
Does the child have fever (by history, feels hot, or temperature ≥37.5°C)?
-
Confirm absence of General Danger Signs.
-
Confirm absence of Stiff Neck.
-
Perform Malaria Test (RDT or Microscopy) - Result is POSITIVE.
Classification
- Fever present AND Malaria test POSITIVE AND No signs of Very Severe Febrile Disease -> MALARIA
Urgency / Refer urgently
Routine Management / Treat with ACT
Management
Non-Pharmacological Management
- Advise adequate fluid intake.
- Advise tepid sponging for comfort if high fever (optional, do not use cold water).
- Continue feeding.
Pharmacological Treatment
- Give first-line oral Artemisinin-based Combination Therapy (ACT): Artemether-Lumefantrine (AL) OR Artesunate-Amodiaquine (AS+AQ).
- AL Dosing (Coartem® 20/120mg tablets, give dose twice daily for 3 days at 0, 8, 24, 36, 48, 60 hours): Weight 5-<15kg (Age 4m-<3y): 1 tablet per dose. Weight 15-<25kg (Age 3-<9y): 2 tablets per dose. Weight 25-<35kg (Age 9-=35kg (Age >14y): 4 tablets per dose. Give with food/fatty drink.
- AS+AQ Dosing (Fixed dose combination, give once daily for 3 days): Refer to specific product dosing based on age/weight bands.
- Give Paracetamol (10-15 mg/kg) if high fever (≥38.5°C axillary) - see dosage on page 15.
- If fever persists every day for more than 7 days, refer for further assessment.
Monitoring & Follow-Up
- Follow-up in 3 days IF fever persists.
- At follow-up: Reassess child fully. If danger signs or stiff neck, treat as Very Severe Febrile Disease and refer. If malaria is only cause of persistent fever, treat with second-line antimalarial (e.g., Quinine) or refer. If other cause identified, treat accordingly.
- If fever has been present > 7 days total, refer for assessment.
Counselling Points
- Explain the diagnosis (malaria) and the need for antimalarial tablets.
- Teach how to give the full course of ACT correctly: dose, timing (especially for AL's 8-hour second dose), duration (3 days), importance of giving with food for AL.
- Teach how to give Paracetamol for high fever.
- Advise on increasing fluids and continuing feeding.
- Advise WHEN TO RETURN IMMEDIATELY: Develops danger signs (cannot drink, vomits everything, convulsions, lethargy), develops stiff neck, becomes sicker.
- Advise to return in 3 days if fever persists, or sooner if condition worsens.
Differential Diagnosis
- Very Severe Febrile Disease (especially Severe Malaria)
- Fever - No Malaria (viral illness, other bacterial infection)
- Pneumonia
- Urinary Tract Infection
- Typhoid fever
- Other febrile illnesses
Potential Complications
- Progression to severe malaria
- Anaemia
- Febrile convulsions
- Dehydration
Prevention
- Sleeping under an Insecticide Treated Net (ITN) every night.
- Indoor residual spraying (IRS) where implemented.
- Prompt diagnosis and effective treatment of malaria episodes.
- Intermittent Preventive Treatment in pregnancy (IPTp) and infancy (IPTi)/Seasonal Malaria Chemoprevention (SMC) where applicable.
Reference: IMCI Chart Booklet - Page 4, Page 15 (AL/AS+AQ, Paracetamol), Page 23 (Follow-up)
TB (Tuberculosis) 2 months - 5 years
Initiate Treatment / Link to TB Clinic
High match
What to tell caregiver
- Explain the diagnosis (TB) and the need for long-term treatment (usually 6 months).
- Explain the importance of taking medications every day exactly as prescribed.
- Teach how to give the TB medicines (crushing/dispersing tablets if needed).
- Explain potential side effects and when to return if they occur (e.g., yellow eyes, skin rash).
- Counsel on good nutrition to support recovery.
- Explain importance of follow-up visits at TB clinic.
- Discuss infection control measures within the household (e.g., cough hygiene, ventilation) if relevant.
- Ask about the caregiver's health (possible source case) and advise screening if needed.
- Counsel on contact tracing for other household members, especially young children.
Classification for a child suspected of having Tuberculosis disease based on symptoms, contact history, and possibly physical signs or diagnostic tests. Requires initiation of TB treatment and linkage to TB clinic.
Key Features
- Diagnosis often based on a combination of symptoms, contact history, and signs, especially in young children where bacteriological confirmation is difficult.
- Criteria differ slightly based on HIV status: >=2 symptoms/signs if HIV Neg, >=1 symptom/sign if HIV Pos.
- Positive contact history is significant.
- Positive GeneXpert or smear microscopy confirms TB.
- Requires multi-drug anti-TB treatment regimen.
Red Flags (Warning Signs)
- Signs of TB meningitis (stiff neck, altered consciousness, convulsions).
- Signs of respiratory distress (severe pneumonia).
- Signs of miliary TB (severe illness, hepatosplenomegaly).
- Signs of spinal TB (back swelling, neurological deficit).
- Any general danger sign.
Assessment
-
Ask (Symptoms suggestive of TB):
-
Has the child been coughing for 14 days or more?
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Has the child had persistent fever (≥14 days)?
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Has the child had poor weight gain in the last month? (Defined as: Weight loss >5% since last visit OR Weight-for-age < -3 Z-score OR Weight-for-age < -2 Z-score OR Growth curve flattening OR Red/Yellow MUAC colour code).
-
Ask (History of contact):
-
Has the child had contact with a person with Pulmonary TB or chronic cough?
-
Look/Feel (Physical signs suggestive of TB):
-
Look/Feel for swellings in the neck or armpit (lymphadenopathy).
-
Look/Feel for swelling on the back (e.g., gibbus).
-
Look/Feel for stiff neck.
-
Listen for persistent wheeze not responding to bronchodilators.
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Check HIV status (HIV positive status increases suspicion/risk).
-
Review available diagnostic tests: Collect sample for GeneXpert or smear microscopy if available. Chest X-Ray results if available.
Classification
- Criteria for TB Classification:
- (HIV Negative Child): Two or more of the following: (Cough ≥14d) OR (Fever ≥14d) OR (Poor weight gain*) OR (Positive contact history) OR (Suggestive physical sign: neck/axilla/back swelling, stiff neck, persistent wheeze).
- (HIV Positive Child): One or more of the following: (Cough ≥14d) OR (Fever ≥14d) OR (Poor weight gain*) OR (Positive contact history) OR (Suggestive physical sign).
- OR A positive GeneXpert or smear microscopy test.
- -> Classify as TB
Urgency / Refer urgently
Initiate Treatment / Link to TB Clinic
Pre-referral treatment
- If signs of severe TB (meningitis, respiratory distress) or other severe classification present, provide appropriate pre-referral treatments (antibiotics, manage danger signs) before urgent referral to hospital (TB treatment may be initiated at hospital).
Management
Non-Pharmacological Management
- Provide nutritional support counselling.
- Counsel on adherence to long-term treatment.
- Trace contacts of the child (especially the source case) for screening.
Pharmacological Treatment
- Initiate TB treatment using appropriate regimen based on national guidelines (typically involves Isoniazid (H), Rifampicin (R), Pyrazinamide (Z), +/- Ethambutol (E) in intensive phase, followed by HR in continuation phase).
- Use weight-band dosing for fixed-dose combinations (FDCs) if available (See Page 19 for RHZ 75/50/150 and E100 weight bands: 4-7kg: 1 tab RHZ, 1 tab E; 8-11kg: 2 tabs RHZ, 2 tabs E; 12-15kg: 3 tabs RHZ, 3 tabs E; 16-24kg: 4 tabs RHZ, 4 tabs E).
- Intensive Phase (First 2 months): Typically 2RHZE or 2RHZ.
- Continuation Phase (Next 4 or 10 months): Typically 4RH or 10RH (longer for TB meningitis/bone TB). See Page 19: 4RH for most forms, 10RH for TB meningitis/osteoarticular TB.
- Link the child to the nearest TB clinic for registration, ongoing treatment, monitoring, and follow-up.
- If GeneXpert or smear microscopy test is not available or negative, but clinical suspicion is high based on criteria, initiate treatment and refer for further assessment/confirmation.
- Treat, counsel, and follow up any co-infections (e.g., HIV, malnutrition).
- If available, give Pyridoxine (Vitamin B6) 12.5mg/day for children <5 years on Isoniazid to prevent neuropathy (absence should not delay starting TB meds).
Monitoring & Follow-Up
- Requires regular follow-up at the TB clinic (e.g., monthly) for monitoring treatment response, side effects, adherence, and weight gain.
- Contact tracing follow-up.
Counselling Points
- Explain the diagnosis (TB) and the need for long-term treatment (usually 6 months).
- Explain the importance of taking medications every day exactly as prescribed.
- Teach how to give the TB medicines (crushing/dispersing tablets if needed).
- Explain potential side effects and when to return if they occur (e.g., yellow eyes, skin rash).
- Counsel on good nutrition to support recovery.
- Explain importance of follow-up visits at TB clinic.
- Discuss infection control measures within the household (e.g., cough hygiene, ventilation) if relevant.
- Ask about the caregiver's health (possible source case) and advise screening if needed.
- Counsel on contact tracing for other household members, especially young children.
Differential Diagnosis
- Persistent bacterial pneumonia
- Asthma (persistent wheeze)
- Chronic lung disease
- Lymphoma or other malignancy (lymphadenopathy)
- HIV-related complications (poor weight gain, fever)
- Malnutrition (poor weight gain)
- Other chronic infections
Potential Complications
- TB Meningitis
- Miliary TB
- Spinal TB (Pott's disease)
- Pleural effusion
- Bronchiectasis
- Treatment failure / Drug resistance
- Drug toxicity (e.g., hepatitis, neuropathy)
- Malnutrition
- Death
Prevention
- BCG vaccination at birth (protects mainly against severe forms like meningitis).
- Isoniazid Preventive Therapy (IPT) for eligible contacts (especially HIV+ children and children <5y who are close contacts) - see TB Exposure classification.
- Early diagnosis and treatment of infectious TB cases (source control).
- Infection control measures (ventilation, cough hygiene).
- HIV prevention and treatment (reduces TB risk).
Reference: IMCI Chart Booklet - Page 9, Page 19 (TB Regimens, Dosing), Page 20 (IPT)